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MTHFR

MTHFR



What is MTHFR?

MTHFR stands for methylenetetrahydrofolate reductase, which is an uncommon hereditary disorder that is linked to complications during pregnancy. It is a blood based disease that causes the blood to clot. Because an affected individual is unable to produce methylenetetrahydrofolate reductase properly, folate (vitmain B9) is not able to be absorbed as it should. Folic acid and B9 are critical to the development of a growing fetus. A lack of folic acid and B9 is linked to malformations and chromosomal abnormalities of a developing baby. In addition, a woman with the genetic mutation may experience elevated levels of homocysteine in the blood, which leads to hyperhomocytenemia. This causes placental disorders, preeclampsia and recurrent pregnancy loss. Some women find out that they have the defective gene throughout testing once they have had several miscarriages.

Symptoms of the disorder include blood clots, depression, anxiety and recurrent miscarriages/stillbirths. In order to diagnose the condition, a woman will undergo blood tests. Women with MTHFR should consume greater amounts of folic acid, which can be found in prenatal vitamins and foods such as eggs, spinach, broccoli, orange juice and beans. Women that are affected with this condition may need to take baby aspirin daily. After being diagnosed with the condition, your health care provider will provide you with additional insturctions on MTHFR.





Comments: MTHFR

Comments 1 to 24 of about 32.
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meshia - 774 days ago.
I had no idea I was born with this condition. Found out I had it when my mother was having her brain surgery. Turns out my brother and I both have it, brother more than me. Was diagnosed 2 years after the birth of my daughter. I am 10 weeks pg with our 2nd. I take a daily prenatal... I am too take other vitamins but I never have. wondering if I should now that I'm pg again. Will go back to the doc for the 12-13 wk scan begin Oct. We shall see.

miracleafterTR - 1189 days ago.
Hi there! I wanted to join this group, and read about some success stories with women who have this mutation. After 5 losses, all at the 5th week or earlier, my RE finally found that I have the MTHFR C-677 T mutation, single (one parent). My RE has me on Folgard (2pills/day), prenatal and I started taking a daily aspirin. I will be taking progesterone after BFP if I get one, but I am still a little nervous! HOPEFUL but nervous. I am not taking anything else..and, not sure if thats okay!!

juliehelton25@yahoo.com - 1199 days ago.
I have MTHFR as well. I have two copies of the mutated gene C677T. So one from both parents. I have had 9 miscarriages due to this disorder. I did no find out that I had this disorder until after two miscarriages when I lost a baby girl at 15 weeks due to a blood clot in the placenta. I was devastated and determined to beat this disorder no matter what cost. I went to all kinds of doctors who did not think that this disorder was that big of a deal and was told at the time after that miscarriage that I could start trying again. I was put on extra folic acid and baby aspirin in addition to my prenatal vitamin, Well this treatment ended up not being aggressive enough for me, I lost three pregnancies with this treatment. Thank God they were all early losses, because to lose one late is heartbreaking. Well, I did not give up trying but I did give up trusting my doctors. I did my own research and discovered that other women were being given heparin shots as soon as they received a positive HPT. So I went to the Doctor handed over my research and told them to do this for me when I became pregnant again. And do you know what? They actually listened to me! And when I became pregnant again, I started the Heparin shots twice daily. And it resulted in me having a healthy baby girl at 37 weeks. She is now almost 6! But that is not the end of my story! I lost three more pregnancies under this same treatment!! I was stumped, it appeared my daughter was a miracle. My husband ended up leaving me because I could not give him a son. And we had been through so much heartbreak losing all those babies. So I resigned to my fate of only having one child, which I was very thankful for!! I never expected to get pregnant again, which is exactly what happened when I met my true husband back in 09. It was a shock to both of us, since we were not even trying! lol This time around the doctors said that research showed that lovenox was better than heparin with MTHFR, so I made the switch. I ended going into preterm labor at 28 weeks and was put on hospital bed rest for three weeks when they my son decided that he was ready to come out and meet us. He was born at 32 weeks 4 days, and stayed in the NICU for a month. He is now 17 months and thriving. Me and dear hubby are now expecting our 2nd child together,and my third. And everything is going great still on the lovenox and I am now 17 weeks pregnant. I recently had an ultrasound and they think it is a boy!

skittles0607 - 1237 days ago.
Seeker- I haev MTHF. I had 2 full term children and then went through 2 m/C. Went and had all of the testing done and thats when they found out about the disorder. Oh and my homocystine levels were also normal..When I got pregnant again I was put on HCG shots 3X a week, baby aspirin daily, lovenox shot daily, and prenantal vitamins I also injected projesterone into my lady parts 2x daily. i was only on the prental vitamin, the lovenox, and the aspirin throughout my entire pregnancy. The HCG and progesterone stopped at 12 weeks After all of thisI finally delivered a healthy baby girl!!

mommyofxyxyxx - 1322 days ago.
I didn't even know this forum existed until today. I have the mthfr mutation. I had two children both born very early with complications including one baby with persistent fetal circulation and the other with a retained placenta that was so clotted up, I bled out for months. I also had two miscarriages. So when ttc again, I had blood work done and they discovered this mutant gene. It's odd but my doctors provided me with so little information, I think there's more on this page than they even told me.I was told to take extra folate and I take lovenox daily then switch to heparin twice daily in the last month. With my third baby (who is 19 months old now), she was born at 39 weeks and was still small but healthy. I'm pregnant with my fourth now and things seem to be going well..so there IS hope. Also of note, I have had severe anxiety and post partum depression with all my babies that eventually goes away with medication. Now, I realize the two things are connected.

dgdaisy - 1331 days ago.
I have MTHFR-single mutation c677t. I have had 3 miscarriages in the last year all under 6 weeks. I am now pregnant and very early and nervous. My levels are much higher than they have ever been and I am hopeful. I am taking heparin shots twice a day, prenatal vitamin, 4mg folic acid, and a baby aspirin. So far so good and hopeful that this time will be different.

seeker - 1337 days ago.
I don't have many details but I do know that I have a mutation on my MTHFR gene. I don't even know if I said that right. Because my homocystiene (sp?) levels were normal, my doctor has determined the mutation has not been the cause of my 4 previous miscarriages. I am desperate for information. If you have a mutation of your MTHFR, have suffered past miscarraiges and either has a baby/child(ren) or is currently pregnant, please share! I think we could all use some encouragement!

redheadmama - 1470 days ago.
Just realized that I haven't put myself on this page. But I wanted to put myself here, as approachable on the subject of MTHFR. I have the homozygous mutation. While ttc, I have to be on daily Lovenox shots, baby aspirin, and Metanx for this condition. While pg, I do the same, but do twice daily Lovenox injections. This is just part of my diagnosis and protocol for treatment, but please know that you are welcome to message my page any time. Blessings!

kbfulloffaith - 1540 days ago.
Hi there - I am 'new' to having MTHFR... I lost my daughter in 2008 at 26 weeks due to HELLP Syndrome. Had a ton of blood tests done found out I have Factor V (1 gene) and MTHFR (1 gene) currently TTC and taking a LDA, prenatal and folic acid vitamin daily, when I get a BFP I'll be on lovenox also...I am nervous - just wanted to hear from ladies doing well...

bbmomma5 - 1588 days ago.
Hello MTHFR Forum. I have hope!! I am currently pregnant with BB # 5/ pregnancy # 6. I lost my baby at week 16 in 2007. (had to give birth and 1 month later a d and c.. it was truely aweful) Testing revieled I have 2 copies of C677T. Since then and forever i'll be on asprin, B vit complex, and Vit D. I carried my first 2 preg to term with toxemia and didnt even know about my condition. With my last 2 sucsessful preg i Suffered prenatal depression so i have preveously been on zoloft as well.. Im (i think) doing well at 9w 2d night now. Im waiting for my next apt at wk 11 to see the bb again just to be reasured that everything is ok. Keep faith!

sweetestgracie - 1614 days ago.
I have MTHFR with both mutations. I have now had 4 miscarriages since 2007. We found out Friday that the baby's heartbeat was gona at 8Weeks 2days. I am ok, but I would just like to figure out everything that is wrong so we can have a baby. I found out about my MTHFR after 3 miscarriages in October 2009. I was on Folic acid (4mg), Prenatal, baby asprin, B12, B6, and prometrium(progesterone) with this past one because of the MTHFR. We still miscarried and they said my homocystine levels were fine 2 days before our miscarriage. It is just hard to keep going through this. We are cosidering adoption, but we would like to have a baby regardless of if we adopt one or not. We had planned on adopting a child after having 2 anyways so it has always been an option for us. Going back to the specialist on Wednesday. I am starting to think it is just a guessing game for the docs as to what to do.

KaySchPreg - 1630 days ago.
Hello I have MTHFR also two copies C677T. This is my second pregnancy and I am on Lovenox 40mg shots daily also a 17p shot once a week. I went to a specialist and was told this should help me go full term. I still get scared of all the meds but if it gets my baby here it is worth it. I lost my first one at 24weeks due to MTHFR. I am now 20 weeks and do not work anymore. There are alot of woman with this and as far as I can tell the Lovenox and 17p shots really help.

leanbean - 1681 days ago.
For me I'm taking folgard(folic acid, b-6 and b12) twice daily, a baby aspirin, extra calcium since the baby aspirin weakens it and a prenatal. I got my homocystein levels tested as soon as I found out I was pregnant and they were nice and normal that's why I'm not on the blood thinners. My last one's heart stopped at just before 8 weeks which is where I am right now. Let's just keep our fingers crossed that this works! Good luck girlies and I think it's great that they're figuring these things out.

trying1moretime - 1681 days ago.
Beckybear, This is such a tricky one, they don't know enough about it and I just hope they are not just guessing with our little ones life. Thanks for your info

beckybear - 1681 days ago.
I just recently found out that I have one copy of the C677t mutation, which I think is supposed to be slightly more severe than having one A mutation. And yet my doctor said it's of no concern to have just one copy of either. I am taking baby aspirin (although I didn't start until recently) and I am going to start taking extra folic, B6, and B12 on my own, but really my doctor didn't seem worried, he went along with the baby aspirin b/c it makes me feel better. I am already just about 10 weeks, so I think I'm way past the window of preventing neural tube defects. I've found conflicting information online about whether or not one mutation needs to be treated during pregnancy. But my previous M/C was at just over 10 weeks, which is suspicious for either a clotting or genetic problem, which is why I didn't want to do nothing and hope for the best this time.

trying1moretime - 1681 days ago.
I went in this week to try to see a heartbeat but only a fetal pole measuring 5w4d when I am LMP 6w2d, hope to see a heartbeat next week. Anyways I have MTHFR A1298C, one mutation, and am on Folbic and baby asprin plus prenatal vitamins 1 time a day. I was wanting to make sure that I could be put on Lovenox once we got a heartbeat. My dr said that she would put me on it if I wanted but she is really dicouraging me because of the risks. She said with on mutation be on Lovenox is more of a risk than not being on it. My husband doesn't want me on it either. I had an abruption with my 1st born, the dr said if I was on the Lovenox and this happened we could both be lost. I don't know what to do anyone else have just one mutation and used Lovenox and if not what are you using. Any suggestions would be appreciated, thanks.

Liandre - 1718 days ago.
Hello ladies. I dont have MTHFR, but i have been diagnosed with anti Phospholipid syndrome after 3 consecutive still births at 28,27 and 27weeks. I am currently pregnant again and i am 14 weeks pregnant. I have to inject my tummy with clexane everyday as well as drinking 81mg of Ecotrin-aspirin. Plus folic acid, calcium and pre natals. I have had 2 live births but i lost my 5 month old son Leigh to SIDS on the 4th november.

go team pink :) - 1726 days ago.
trying1moretime- i am on exactly the same treatment... i had a placental abruption at 21 weeks and lost my little boy about 4 years ago and didnt find out till i was pregnant again about my mthfr. the type we have up to 60% of the population have but dont know about it. im on 150 mg of b6 and b12 a day to lower my homocystine leves, 100mg of asprin a day to thin my blood a 10 times dose of folate ( 5 mg) and a pre natal. apparently the sucsess rate is very good:). my second little man is 2 now and his perfect and iv made it 9 weeks so far in my current pregnancy....best of luck

LHarpe - 1735 days ago.
I'm on my third pregnacy, and I just found out that I have 2 mutations of MTHFR. My first pregnacy seemed to be fine, but I had a stroke with my second one at about 20 weeks. My baby was fine. I was put on injections of lovenox and baby aspirn cause of it. Took me 4 years to get the nerve to have another baby, but I am pregnant now. Everything is fine..... so far. I am taking the lovenox and baby aspirn again. I got to say that I am so worried. I am here if anyone would like to talk.

skittles0607 - 1745 days ago.
Trying1moretime- I also have MTHFR. I have 2 copies though. I am on daily injections of lovenox, baby aspirin and the regular prenantal vitamin.. When I first found out I was pregnant I was on all of that plu injections of HCG 3 times a week and progesterone supp 2 times a day. I had 2 full term pregnancies, then 2 m/cs at 13 weeks, then diagnosed with MTHFR. I am now 27 weeks pregnant!!! If you would like to join us in the Pregnancy after loss you are more than welcome. There are a few of us in there who are taking blood thinners.. Its very supportive in there as well.

trying1moretime - 1745 days ago.
After my MCs the doctor did blood work and found out that I have MTHFR A1298C Heterozygous, which from what I understand if you have it this is the lesser of kind. My doctor gave me folbic along with prenatal vitamin and baby asprin daily. I am just wondering if anyone has had this kind and every had the injections once you have gotten pregnant?

VASSO01 - 1758 days ago.
I'm homozygous for the MTHFR,but the actual levels of homocysteine in my blood are ok.I'm 8w5d now and i take folic acid and have injections on my belly,daily.I'm scared because i had a miscarriage last June(after 1,5 years of trying to get pregnant) ,but i hope everything goes fine this time.

miraclemom3 - 1765 days ago.
I have known for 3 years that I am compound Hetero for MTHFR after 3 M/C at 5,17, and 15 weeks. I am currently 21 weeks PG with a sweet little boy! I am taking 40mg Lovenox daily as well as folic acid and baby aspirin. I have had no complications thus far and just praying for a healthy full term baby.

traemomma - 1800 days ago.
I was just informed a couple days ago that I have MTHFR. I have had 3 miscarriages and one son was born at 28 weeks, I'm currenty 23 weeks pregnant with my daughter. Please feel free to fill me in with any info you might have!

leanbean - 1803 days ago.
I FOUND OUT I HAVE MTHFR ABOUT A WEEK AGO AND I'M TTC AFTER A M/C 2 MONTHS AGO. JUST FOUND OUT 2 OF MY SISTERS HAVE THIS AS WELL. WE JUST HAVE THE ONE FACTOR, BUT ONE OF MY SISTERS EXPERIENCED A LOSS AS WELL AND A PULMANARY EMBOLISM WHILE PREGNANT AND THANKFULLY RECOVERED AS WELL AS GOING ON TO DELIVER A HEALTHY BABY WHO'S NOW 7.


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