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The best example is when an Rh-negative woman is pregnant with an Rh-positive baby. The woman`s immune system can develop an antibody that attaches to the Rh-positive antigens on her baby`s red blood cells and target them for destruction. Although it is unusual for her first Rh-positive baby to become ill, the antibodies produced during that first pregnancy will affect any future Rh-positive babies. To greatly reduce the likelihood that an Rh-negative mother will develop this antibody, she may be given a routine injection of Rh immune globulin (RhoGam) at approximately 28 weeks gestation. Additional injections may be necessary during the pregnancy if she has an amniocentesis, chorionic villi sampling, or an abdominal injury, and after delivery if the baby is Rh-positive. Before each injection is given, an antibody screen is performed to make sure that the woman has not already created Rh antibodies. |
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